Article

INCB24360 Suppresses M1-like Macrophage Formation and NLRP3 Expression Whereas Increases IL-1β Secretion in RAW264.7 and BV-2

2020-12-23

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Macrophages switch between different functional phenotypes under the different physiological or path-physiological stimuli in tissue. Macrophage functional phenotype heavily affects disease progression, including inflammation, injury, neurodegenerative disease, and cancers. IDO-1, a druggable target, is an immunosuppressive enzyme expressed in tissue macrophages...

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Literature Corpus work: 8c889283-130f-5ad9-a4d1-5d850a946f33
DOI: 10.21203/rs.3.rs-131426/v1

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