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Article

Selective killing of human M1 macrophages by Smac mimetics alone and M2 macrophages by Smac mimetics and caspase inhibition.

Journal of leukocyte biology - 1 Oct 2021

Ali Hamza, Caballero Ramon, Dong Simon X M, Gajnayaka Niranjala, Vranjkovic Agatha, Ahmed Duale, Iqbal Salma, Crawley Angela M, Angel Jonathan B, Cassol Edana, Kumar Ashok

Abstract excerpt

The inflammatory and anti-inflammatory Mϕs have been implicated in many diseases including rheumatoid arthritis, multiple sclerosis, and leprosy. Recent studies suggest targeting Mϕ function and activation may represent a potential target to treat these diseases. Herein, we investigated the effect of second mitochondria-derived activator of caspases (SMAC) mimetics (SMs), the inhibitors of apoptosis (IAPs)...

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PMID: 33404106
DOI: 10.1002/JLB.4A0220-114RR

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