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Article

Primary human monocytes differentiate into M2 macrophages and involve Notch-1 pathway.

Canadian journal of physiology and pharmacology - 1 Mar 2017

Singla Dinender K, Wang Jing, Singla Reetu

Abstract excerpt

The current study investigates whether inhibiting the Notch-1 signaling pathway in primary human monocytes enhances M2 macrophage differentiation. We generated a primary human monocyte cell culture model to understand the effect of the Notch-1 signaling pathway. Monocytes were treated with Notch-1 inhibitors DAPT or siRNA. Our data show that there was a significant increase in the M1 macrophage population...

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Identifiers

PMID: 28238274
DOI: 10.1139/cjpp-2016-0319

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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