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The C57Bl/6J mouse strain is more susceptible to angiotensin II-induced aortic aneurysm formation than C57Bl/6N.

Atherosclerosis - 1 Feb 2021

Wortmann Markus, Arshad Muhammad, Peters Andreas S, Hakimi Maani, Böckler Dittmar, Dihlmann Susanne

Abstract excerpt

BACKGROUND AND AIMS: Genetic variations between C57Bl/6 mouse substrains are highly relevant to the investigation of cardiovascular disease. We here assessed whether these variations have an impact on the incidence of abdominal aortic aneurysms (AAA) in C57Bl/6J and 6 N mice. METHODS: AAA were induced by subcutaneous infusion of 1500 ng/kg*min Angiotensin-II for four weeks in six-month-old male CB57Bl/6J and 6N...

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Identifiers

PMID: 33348068
DOI: 10.1016/j.atherosclerosis.2020.11.032

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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