Article
Differential gender- and species-specific formation of aneurysms using a novel method of inducing abdominal aortic aneurysms.
The Journal of surgical research - 1 Dec 2012
Laser Adriana, Lu Guanyi, Ghosh Abhijit, Roelofs Karen, McEvoy Brendan, DiMusto Paul, Bhamidipati Castigliano M, Su Gang, Zhao Yunge, Lau Christine L, Ailawadi Gorav, Eliason Jonathan L, Henke Peter K, Upchurch Gilbert R
Abstract excerpt
BACKGROUND: The objective of this study was to test a novel model of inducing abdominal aortic aneurysms (AAAs) in different mouse strains and genders. MATERIALS AND METHODS: Male and female C57BL/6 and B6129 mice (n = 5 per group) underwent periaortic dissection and porcine pancreatic elastase (30 μL) or inactivated elastase application (5 min) to the aorta. Aortic measurements were taken on days 0 and 14....
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