Article
Elevated Plasma Levels of LDL Cholesterol Promote Dissecting Thoracic Aortic Aneurysms in Angiotensin II-Induced Mice.
Annals of vascular surgery - 1 Apr 2018
Tanaka Hiroki, Iida Yasunori, Iwaki Takayuki, Suzuki Yuko, Sano Hideto, Miyajima Chiharu, Zaima Nobuhiro, Sasaki Takeshi, Sumioka Ayato, Hakamata Shogo, Shimizu Hideyuki, Umemura Kazuo, Urano Tetsumei
Abstract excerpt
BACKGROUND: Plasma low-density lipoprotein (LDL) cholesterol is implicated in abdominal aorta (AA) and aortic dissection (AD); however, its role in the pathogenesis of AA and AD, a disease with a high mortality rate, is unknown. The existing animal models such as apolipoprotein E-deficient (Apoe-/-) mice cannot reproduce all the conditions of AA/AD, including elevated LDL-cholesterol levels and spontaneous...
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