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Article

Absence of Nicotinamide Nucleotide Transhydrogenase in C57BL/6J Mice Exacerbates Experimental Atherosclerosis.

Journal of vascular research - 1 Jan 2018

Vozenilek Aimee E, Vetkoetter Matthew, Green Jonette M, Shen Xinggui, Traylor James G, Klein Ronald L, Orr A Wayne, Woolard Matthew D, Krzywanski David M

Abstract excerpt

BACKGROUND: Mitochondrial reactive oxygen species (ROS) contribute to inflammation and vascular remodeling during atherosclerotic plaque formation. C57BL/6N (6N) and C57BL/6J (6J) mice display distinct mitochondrial redox balance due to the absence of nicotinamide nucleotide transhydrogenase (NNT) in 6J mice. We hypothesize that differential NNT expression between these animals alters plaque development. METHODS:...

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Identifiers

PMID: 29455203
DOI: 10.1159/000486337
PMCID: PMC6287760

Genes

NNT
PCSK9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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