Article
Direct evidence for a crucial role of the arterial wall in control of atherosclerosis susceptibility.
Circulation - 28 Nov 2006
Pei Hong, Wang Yinong, Miyoshi Toru, Zhang Zhimin, Matsumoto Alan H, Helm Gregory A, Tellides George, Shi Weibin
Abstract excerpt
BACKGROUND: Inbred mouse strains C57BL/6J (B6) and C3H/HeJ (C3H) exhibit marked differences in atherosclerosis susceptibility. We sought to determine whether the difference in atherosclerosis susceptibility resides at the level of arterial walls. METHODS AND RESULTS: Thoracic aortic segments from 8-week-old female B6 and C3H apolipoprotein E-deficient mice were transplanted into the infrarenal aorta of...
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