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Article

CFAP53 regulates mammalian cilia-type motility patterns through differential localization and recruitment of axonemal dynein components.

PLoS genetics - 1 Dec 2020

Ide Takahiro, Twan Wang Kyaw, Lu Hao, Ikawa Yayoi, Lim Lin-Xenia, Henninger Nicole, Nishimura Hiromi, Takaoka Katsuyoshi, Narasimhan Vijay, Yan Xiumin, Shiratori Hidetaka, Roy Sudipto, Hamada Hiroshi

Abstract excerpt

Motile cilia can beat with distinct patterns, but how motility variations are regulated remain obscure. Here, we have studied the role of the coiled-coil protein CFAP53 in the motility of different cilia-types in the mouse. While node (9+0) cilia of Cfap53 mutants were immotile, tracheal and ependymal (9+2) cilia retained motility, albeit with an altered beat pattern. In node cilia, CFAP53 mainly localized at the...

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Identifiers

PMID: 33347437
DOI: 10.1371/journal.pgen.1009232
PMCID: PMC7817014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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