Article
Characterization of tetratricopeptide repeat-containing proteins critical for cilia formation and function.
PloS one - 1 Jan 2015
Xu Yanan, Cao Jingli, Huang Shan, Feng Di, Zhang Wei, Zhu Xueliang, Yan Xiumin
Abstract excerpt
Cilia formation and function require a special set of trafficking machinery termed intraflagellar transport (IFT), consisting mainly of protein complexes IFT-A, IFT-B, BBSome, and microtubule-dependent molecular motors. Tetratricopeptide repeat-containing (TTC) proteins are widely involved in protein complex formation. Nine of them are known to serve as components of the IFT or BBSome complexes. How many TTC...
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