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Article

Airway ciliary microenvironment responses in mice with primary ciliary dyskinesia and central pair apparatus defects.

Scientific reports - 18 Nov 2024

McKenzie Casey W, Wilcox Reesa M, Isaiah Oduduabasi J, Kareta Michael S, Lee Lance

Abstract excerpt

Dysfunction of motile cilia can impair mucociliary clearance in the airway and result in primary ciliary dyskinesia (PCD). We previously showed that mutations in central pair apparatus (CPA) genes perturb ciliary motility and result in PCD in mouse models. However, little is known about how epithelial cell types in the ciliary microenvironment of the upper airway respond to defects in ciliary motility and...

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Identifiers

PMID: 39558053
DOI: 10.1038/s41598-024-79877-z
PMCID: PMC11574124

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