Article
Loss of MACF1 Abolishes Ciliogenesis and Disrupts Apicobasal Polarity Establishment in the Retina.
Cell reports - 25 Oct 2016
May-Simera Helen L, Gumerson Jessica D, Gao Chun, Campos Maria, Cologna Stephanie M, Beyer Tina, Boldt Karsten, Kaya Koray D, Patel Nisha, Kretschmer Friedrich, Kelley Matthew W, Petralia Ronald S, Davey Megan G, Li Tiansen
Abstract excerpt
Microtubule actin crosslinking factor 1 (MACF1) plays a role in the coordination of microtubules and actin in multiple cellular processes. Here, we show that MACF1 is also critical for ciliogenesis in multiple cell types. Ablation of Macf1 in the developing retina abolishes ciliogenesis, and basal bodies fail to dock to ciliary vesicles or migrate apically. Photoreceptor polarity is randomized, while inner...
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