Article

Drosophila Ttc12 genes are putative co-chaperones for dynein assembly and docking in motile cilia

2020-01-01

Abstract excerpt

Motile cilia have many developmental and physiological functions. The hallmark of motile cilia are their axonemal dynein motor proteins that generate movement. These large protein complexes require cytoplasmic pre-assembly prior to transport and docking in the cilium, together with an array of associated support complexes, including nexin-DRC and radial spokes. Motile cilia reside in a number of epithelial surface...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1e1ef6cb-f80d-590f-ad32-ee26e1c0b094
DOI: 10.7488/era/150

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Drosophila Ttc12 genes are putative co-chaperones for dynein assembly and docking in motile ciliaDOI 10.7488/era/150Read

TTC12 Loss-of-Function Mutations Cause Primary Ciliary Dyskinesia and Unveil Distinct Dynein Assembly Mechanisms in Motile Cilia Versus Flagella.Semantic proximity Read

Ciliary Dyneins and Dynein Related CiliopathiesSemantic proximity Read

Consensus nomenclature for dyneins and associated assembly factors.Semantic proximity Read

TCTE1 is a conserved component of the dynein regulatory complex and is required for motility and metabolism in mouse spermatozoa.Semantic proximity Read

Loss-of-Function GAS8 Mutations Cause Primary Ciliary Dyskinesia and Disrupt the Nexin-Dynein Regulatory Complex.Semantic proximity Read

Pathogenic variants in CLXN encoding the outer dynein arm docking-associated calcium-binding protein calaxin cause primary ciliary dyskinesia.Semantic proximity Read

Splice-site mutations in the axonemal outer dynein arm docking complex gene CCDC114 cause primary ciliary dyskinesia.Semantic proximity Read

Strongly truncated <i>Dnaaf4</i> plays a conserved role in <i>Drosophila</i> ciliary dynein assembly as part of an R2TP-like co-chaperone complex with <i>Dnaaf6</i>Semantic proximity Read

CCDC151 mutations cause primary ciliary dyskinesia by disruption of the outer dynein arm docking complex formation.Semantic proximity Read

Architecture of the IFT ciliary trafficking machinery and interplay between its componentsSemantic proximity Read

Mutations in GAS8, a Gene Encoding a Nexin-Dynein Regulatory Complex Subunit, Cause Primary Ciliary Dyskinesia with Axonemal Disorganization.Semantic proximity Read

Ktu/PF13 is required for cytoplasmic pre-assembly of axonemal dyneins.Semantic proximity Read