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Article

Early life imprints the hierarchy of T cell clone sizes

21 Dec 2020

Abstract excerpt

The adaptive immune system responds to pathogens by selecting clones of cells with specific receptors. While clonal selection in response to particular antigens has been studied in detail, it is unknown how a lifetime of exposures to many antigens collectively shape the immune repertoire. Here, using mathematical modeling and statistical analyses of T cell receptor sequencing data, we develop a quantitative...

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PMID: 33345776
DOI: 10.7554/elife.61639

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