Article
Convergence and divergence of individual immune responses over the life course.
Science (New York, N.Y.) - 7 Aug 2025
Metcalf C Jessica E, Graham Andrea L, Yates Andrew J, Cummings Derek A T
Abstract excerpt
Three ingredients create the strikingly variable immune trajectories observed across human populations: (i) genetic variation, (ii) individual-scale generation of additional genetic diversity solely in lymphocytes, and (iii) collision of these processes with a changing environment through life, triggering plastic responses that can have lasting effects. We explore what generates or reduces immune variation,...
Topics
- Animals
- Humans
- Adaptive Immunity
- Biological Evolution
- Genetic Variation
- Homeostasis
- Immune System
- Immunity
- Immunity, Innate
- Immunologic Memory
- Lymphocytes
- Biological Variation, Individual