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Heterologous expression of the atypical tetracycline chelocardin reveals the full set of genes required for its biosynthesis

1 Dec 2020

Abstract excerpt

BACKGROUND: Chelocardin (CHD) exhibits a broad-spectrum antibiotic activity and showed promising results in a small phase II clinical study conducted on patients with urinary tract infections. Importantly, CHD was shown to be active also against tetracycline-resistant Gram-negative pathogens, which is gaining even more importance in today's antibiotic crisis. We have demonstrated that modifications of CHD through...

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PMID: 33341113
DOI: 10.1186/s12934-020-01495-x

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