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Genome Mining‐Directed Activation of a Silent Angucycline Biosynthetic Gene Cluster in <i>Streptomyces chattanoogensis</i>

15 Dec 2014

Abstract excerpt

Genomic sequencing of actinomycetes has revealed the presence of numerous gene clusters seemingly capable of natural product biosynthesis, yet most clusters are cryptic under laboratory conditions. Bioinformatics analysis of the completely sequenced genome of Streptomyces chattanoogensis L10 (CGMCC 2644) revealed a silent angucycline biosynthetic gene cluster. The overexpression of a pathway-specific activator...

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PMID: 25511454
DOI: 10.1002/cbic.201402577

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