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Article

Study of bicyclomycin biosynthesis in Streptomyces cinnamoneus by genetic and biochemical approaches.

Scientific reports - 27 Dec 2019

Witwinowski Jerzy, Moutiez Mireille, Coupet Matthieu, Correia Isabelle, Belin Pascal, Ruzzini Antonio, Saulnier Corinne, Caraty Laëtitia, Favry Emmanuel, Seguin Jérôme, Lautru Sylvie, Lequin Olivier, Gondry Muriel, Pernodet Jean-Luc, Darbon Emmanuelle

Abstract excerpt

The 2,5-Diketopiperazines (DKPs) constitute a large family of natural products with important biological activities. Bicyclomycin is a clinically-relevant DKP antibiotic that is the first and only member in a class known to target the bacterial transcription termination factor Rho. It derives from cyclo-(L-isoleucyl-L-leucyl) and has an unusual and highly oxidized bicyclic structure that is formed by an ether...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31882990
DOI: 10.1038/s41598-019-56747-7
PMCID: PMC6934819

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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