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Article

Engineering Streptomyces coelicolor for heterologous expression of secondary metabolite gene clusters.

Microbial biotechnology - 1 Mar 2011

Gomez-Escribano Juan Pablo, Bibb Mervyn J

Abstract excerpt

We have constructed derivatives of Streptomyces coelicolor M145 as hosts for the heterologous expression of secondary metabolite gene clusters. To remove potentially competitive sinks of carbon and nitrogen, and to provide a host devoid of antibiotic activity, we deleted four endogenous secondary metabolite gene clusters from S. coelicolor M145--those for actinorhodin, prodiginine, CPK and CDA biosynthesis. We...

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Identifiers

PMID: 21342466
DOI: 10.1111/j.1751-7915.2010.00219.x
PMCID: PMC3818861

Genes

CDA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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