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Article

Epigenetic differences at the HTR2A locus in progressive multiple sclerosis patients.

Scientific reports - 17 Dec 2020

Maltby Vicki E, Lea Rodney A, Burnard Sean, Xavier Alexandre, Van Cao Thao, White Nicole, Kennedy Daniel, Groen Kira, Sanders Katherine A, Seeto Rebecca, Bray Samara, Gresle Melissa, Laverick Louise, Butzkueven Helmut, Scott Rodney J, Lechner-Scott Jeannette

Abstract excerpt

The pathology of progressive multiple sclerosis (MS) is poorly understood. We have previously assessed DNA methylation in the CD4+ T cells of relapsing-remitting (RR) MS patients compared to healthy controls and identified differentially methylated regions (DMRs) in HLA-DRB1 and RNF39. This study aimed to investigate the DNA methylation profiles of the CD4+ T cells of progressive MS patients. DNA methylation was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptor, Serotonin, 5-HT2A

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Identifiers

PMID: 33335118
DOI: 10.1038/s41598-020-78809-x
PMCID: PMC7747721

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