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Article

Differential methylation at MHC in CD4+ T cells is associated with multiple sclerosis independently of HLA-DRB1.

Clinical epigenetics - 1 Jan 2017

Maltby Vicki E, Lea Rodney A, Sanders Katherine A, White Nicole, Benton Miles C, Scott Rodney J, Lechner-Scott Jeannette

Abstract excerpt

BACKGROUND: Although many genetic variants have been associated with multiple sclerosis (MS) risk, they do not explain all the disease risk and there remains uncertainty as to how these variants contribute to disease. DNA methylation is an epigenetic mechanism that can influence gene expression and has the potential to mediate the effects of environmental factors on MS. In a previous study, we found a...

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Share to Amidohydrolases
Share to CD4-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CpG Islands

Share to Epigenesis, Genetic

Share to HLA-DRB1 Chains

Share to Immediate-Early Proteins

Share to Multiple Sclerosis, Relapsing-Remitting

Share to RNA, Long Noncoding

Source

Open in PubMed Open full text

Identifiers

PMID: 28729889
DOI: 10.1186/s13148-017-0371-1
PMCID: PMC5516341

Genes

RNF39
ERICH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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