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Article

Effect of ABC transporter expression and mutational status on survival rates of cancer patients.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Nov 2020

Kadioglu Onat, Saeed Mohamed E M, Munder Markus, Spuller Andreas, Greten Henry Johannes, Efferth Thomas

Abstract excerpt

ATP-binding cassette (ABC) transporters mediate multidrug resistance in cancer. In contrast to DNA single nucleotide polymorphisms in normal tissues, the role of mutations in tumors is unknown. Furthermore, the significance of their expression for prediction of chemoresistance and survival prognosis is still under debate. We investigated 18 tumors by RNA-sequencing. The mutation rate varied from 27,507 to 300885....

Topics

ATP-Binding Cassette Transporters
Adult
Aged
Aged, 80 and over
Female
Humans
Male
Middle Aged
Molecular Docking Simulation
Mutation
Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Sequence Analysis, RNA

Survival Rate

Source

Identifiers

PMID: 32932043
DOI: 10.1016/j.biopha.2020.110718

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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