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Article

GADGETS: a genetic algorithm for detecting epistasis using nuclear families.

Bioinformatics (Oxford, England) - 27 Jan 2022

Nodzenski Michael, Shi Min, Krahn Juno M, Wise Alison S, Li Yuanyuan, Li Leping, Umbach David M, Weinberg Clarice R

Abstract excerpt

MOTIVATION: Epistasis may play an etiologic role in complex diseases, but research has been hindered because identification of interactions among sets of single nucleotide polymorphisms (SNPs) requires exploration of immense search spaces. Current approaches using nuclear families accommodate at most several hundred candidate SNPs. RESULTS: GADGETS detects epistatic SNP-sets by applying a genetic algorithm to...

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PMID: 34788792
DOI: 10.1093/bioinformatics/btab766
PMCID: PMC10060691

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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