Article
Dysfunction of VIPR2 leads to myopia in humans and mice.
Journal of medical genetics - 1 Jan 2022
Zhao Fuxin, Li Qihang, Chen Wei, Zhu He, Zhou Dengke, Reinach Peter Sol, Yang Zhenglin, He Mingguang, Xue Anquan, Wu Deng, Liu Tianzi, Fu Qian, Zeng Changqing, Qu Jia, Zhou Xiangtian
Abstract excerpt
BACKGROUND: Myopia is the leading cause of refractive errors. As its pathogenesis is poorly understood, we determined if the retinal VIP-VIPR2 signalling pathway axis has a role in controlling signalling output that affects myopia development in mice. METHODS: Association analysis meta-study, single-cell transcriptome, bulk RNA sequencing, pharmacological manipulation and VIPR2 gene knockout studies were used to...
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