Article

LRP2 is a potential molecular target for pathological myopia

2025-03-10

Abstract excerpt

High myopia (HM) and posterior staphyloma (PS) are major causes of vision loss worldwide. Genetic and environmental factors, especially light exposure, contribute to myopia. Mutations in low-density lipoprotein-related receptor type 2, LRP2 cause syndromic myopia, and the Foxg1-Cre-Lrp2lox/lox mouse is a model for myopia and PS but the involvement of LRP2 in non-syndromic HM (NSHM) was unknown. We showed that LRP2...

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Literature Corpus work: bc6459a8-f525-5880-863e-de981a559341
DOI: 10.1101/2025.03.04.641381

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