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Probing the VIPR2 Microduplication Linkage to Schizophrenia in Animal and Cellular Models

22 Jul 2021

Abstract excerpt

Pituitary adenylate cyclase-activating polypeptide (PACAP, gene name ADCYAP1) is a multifunctional neuropeptide involved in brain development and synaptic plasticity. With respect to PACAP function, most attention has been given to that mediated by its specific receptor PAC1 (ADCYAP1R1). However, PACAP also binds tightly to the high affinity receptors for vasoactive intestinal peptide (VIP, VIP), called VPAC1 and...

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PMID: 34366784
DOI: 10.3389/fnins.2021.717490

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