Article
Loss of Gap Junction Delta-2 (GJD2) gene orthologs leads to refractive error in zebrafish.
Communications biology - 3 Jun 2021
Quint Wim H, Tadema Kirke C D, de Vrieze Erik, Lukowicz Rachel M, Broekman Sanne, Winkelman Beerend H J, Hoevenaars Melanie, de Gruiter H Martijn, van Wijk Erwin, Schaeffel Frank, Meester-Smoor Magda, Miller Adam C, Willemsen Rob, Klaver Caroline C W, Iglesias Adriana I
Abstract excerpt
Myopia is the most common developmental disorder of juvenile eyes, and it has become an increasing cause of severe visual impairment. The GJD2 locus has been consistently associated with myopia in multiple independent genome-wide association studies. However, despite the strong genetic evidence, little is known about the functional role of GJD2 in refractive error development. Here, we find that depletion of...
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