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Article

Multi-sample measurement of hyperpolarized pyruvate-to-lactate flux in melanoma cells.

NMR in biomedicine - 1 Mar 2021

Lees Hannah, Millan Micaela, Ahamed Fayyaz, Eskandari Roozbeh, Granlund Kristin L, Jeong Sangmoo, Keshari Kayvan R

Abstract excerpt

Hyperpolarized [1-13 C] pyruvate can be used to examine the metabolic state of cancer cells, highlighting a key metabolic characteristic of cancer: the upregulated metabolic flux to lactate, even in the presence of oxygen (Warburg effect). Thus, the rate constant of 13 C exchange of pyruvate to lactate, kPL , can serve as a metabolic biomarker of cancer presence, aggressiveness and therapy response. Established...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33314422
DOI: 10.1002/nbm.4447
PMCID: PMC8288443

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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