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Article

The BRAF Inhibitor Vemurafenib Activates Mitochondrial Metabolism and Inhibits Hyperpolarized Pyruvate-Lactate Exchange in BRAF-Mutant Human Melanoma Cells.

Molecular cancer therapeutics - 1 Dec 2016

Delgado-Goni Teresa, Miniotis Maria Falck, Wantuch Slawomir, Parkes Harold G, Marais Richard, Workman Paul, Leach Martin O, Beloueche-Babari Mounia

Abstract excerpt

Understanding the impact of BRAF signaling inhibition in human melanoma on key disease mechanisms is important for developing biomarkers of therapeutic response and combination strategies to improve long-term disease control. This work investigates the downstream metabolic consequences of BRAF inhibition with vemurafenib, the molecular and biochemical processes that underpin them, their significance for...

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Source

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Identifiers

PMID: 27765851
DOI: 10.1158/1535-7163.MCT-16-0068
PMCID: PMC5136471

Genes

BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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