Conservation and divergence of metabolic phenotypes between patient tumours and matched xenografts.

doi:10.1038/s42255-025-01338-2

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Article

Conservation and divergence of metabolic phenotypes between patient tumours and matched xenografts.

Nature metabolism - 1 Aug 2025

Rao Aparna D, Cai Ling, Snyman Marelize, Walsdorf Rachel E, Li Xiangyi, Wix Sophia N, Gard Gabrielle, Brown Ariel B, Kim Juliana, Santos Patricio Joao, Muh Sarah, Martin Sandoval Misty, Zacharias Lauren G, Heimdal Kristen A, Gu Wen, Homsi Jade, Tillman Brittny, Sharma Rohit, Vandergriff Travis W, Solmonson Ashley, Faubert Brandon, Mathews Thomas P, Morrison Sean J, DeBerardinis Ralph J, Gill Jennifer G

Abstract excerpt

Patient-derived xenografts (PDXs) are frequently used as preclinical models, but their recapitulation of tumour metabolism in patients has not been closely examined. We developed a parallel workflow to analyse [U-13C]glucose tracing and metabolomics data from patient melanomas and matched PDXs. Melanomas from patients have substantial TCA cycle labelling, similar to levels in human brain tumours. Although levels...

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PMID: 40731149
DOI: 10.1038/s42255-025-01338-2
PMCID: PMC12373500

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