Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The complement C3‐C3aR pathway mediates microglia–astrocyte interaction following status epilepticus

14 Dec 2020

Abstract excerpt

Abstract Gliosis is a histopathological characteristic of epilepsy that comprises activated microglia and astrocytes. It is unclear whether or how crosstalk occurs between microglia and astrocytes in the evolution of epilepsy. Here, we report in a mouse model of status epilepticus, induced by intracerebroventricular injection of kainic acid (KA), sequential activation of microglia and astrocytes and their close...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Complement system in diseases
Share to Neonatal and fetal brain pathology
Share to Neuroinflammation and Neurodegeneration Mechanisms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33314324
DOI: 10.1002/glia.23955

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The complement C3‐C3aR pathway mediates microglia–astrocyte interaction following status epilepticusPMID 33314324Read ↗

Cannabidiol protects against neurotoxic reactive astrocytes-induced neuronal death in mouse models of epilepsySemantic proximity Read ↗

Impaired microglial phagocytosis promotes seizure developmentSemantic proximity Read ↗

The Complement System: A Powerful Modulator and Effector of Astrocyte Function in the Healthy and Diseased Central Nervous System.Semantic proximity Read ↗

Neuroinflammation: A Signature or a Cause of Epilepsy?Semantic proximity Read ↗

Spatiotemporal patterns of gliosis and neuroinflammation in presenilin 1/2 conditional double knockout miceSemantic proximity Read ↗

Diisopropylfluorophosphate-induced status epilepticus drives complex glial cell phenotypes in adult male mice.Semantic proximity Read ↗

Targeting Microglial Activation in Drug-Resistant Epilepsy: Emerging Therapeutic StrategiesSemantic proximity Read ↗

Investigating inflammatory pathways as therapeutic targets and biomarkers using functional imaging and pharmacological interventions in epilepsy modelsSemantic proximity Read ↗

Role of Astrocytic and Microglial Phenotype in the Biology of Hippocampal Sclerosis.Semantic proximity Read ↗

The Receptor for Complement Anaphylatoxin C3a Is Expressed by Myeloid Cells and Nonmyeloid Cells in Inflamed Human Central Nervous System: Analysis in Multiple Sclerosis and Bacterial MeningitisSemantic proximity Read ↗

Chronic activation of astrocytic G <sub>q</sub> GPCR signaling has causal effects on visual LTP formation: implications for neurodegenerative diseasesSemantic proximity Read ↗

Inhibition of Endocannabinoid Degradation in Astrocytes Reprograms Glial Reactivity and Prevents Seizure SequelaeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.