Article
Role of Astrocytic and Microglial Phenotype in the Biology of Hippocampal Sclerosis.
Neuropathology and applied neurobiology - 1 Oct 2025
Goyal Aditi, Rao Shilpa, Saha Amit Kumar, Sugur Harsha, Poulose Roshni, Shirke Omkar, Mohanraj Nivedha, Mehta Bhupesh, Philip Mariamma, Arivazhagan A, Saini Jitender, Vishwanathan L G, Asranna Ajay, Raghavendra K, Mundlamuri R C, Sadashiva Nishanth, Bharath R D, Karthik K, Sandhya M, Rao Malla Bhaskara, Sinha Sanjib, Mahadevan Anita
Abstract excerpt
AIMS: Astrocytic and microglial phenotypes (A1/A2 and M1/M2, respectively) with neuro-inflammatory and neuroprotective roles are key players in the pathogenesis of several neurological diseases. However, their role in epilepsy is underexplored. We investigated astrocytic and microglial phenotypes in the pathogenesis of epileptogenesis in hippocampal sclerosis (HS), causing drug-resistant temporal lobe epilepsy....
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