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Spatiotemporal patterns of gliosis and neuroinflammation in presenilin 1/2 conditional double knockout mice

14 Sept 2022

Abstract excerpt

Increasing evidence indicates that neuroinflammation contributes to and exacerbates the pathogenesis of Alzheimer's disease (AD). Neuroinflammation is thought to be primarily driven by glial cells (microglia and astrocytes) and escalates with neurodegenerative progression in AD. However, the spatiotemporal change patterns of glial reactivity and neuroinflammatory response during different stages of...

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PMID: 36185485
DOI: 10.3389/fnagi.2022.966153

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