Article
Myeloid Cell-Derived Reactive Oxygen Species Induce Epithelial Mutagenesis.
Cancer cell - 11 Dec 2017
Canli Özge, Nicolas Adele M, Gupta Jalaj, Finkelmeier Fabian, Goncharova Olga, Pesic Marina, Neumann Tobias, Horst David, Löwer Martin, Sahin Ugur, Greten Florian R
Abstract excerpt
Increased oxidative stress has been suggested to initiate and promote tumorigenesis by inducing DNA damage and to suppress tumor development by triggering apoptosis and senescence. The contribution of individual cell types in the tumor microenvironment to these contrasting effects remains poorly understood. We provide evidence that during intestinal tumorigenesis, myeloid cell-derived H2O2 triggers genome-wide...
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