Article
HLA-A SNPs and amino acid variants are associated with nasopharyngeal carcinoma in Malaysian Chinese.
International journal of cancer - 1 Feb 2015
Chin Yoon-Ming, Mushiroda Taisei, Takahashi Atsushi, Kubo Michiaki, Krishnan Gopala, Yap Lee-Fah, Teo Soo-Hwang, Lim Paul Vey-Hong, Yap Yoke-Yeow, Pua Kin-Choo, Kamatani Naoyuki, Nakamura Yusuke, Sam Choon-Kook, Khoo Alan Soo-Beng, Ng Ching-Ching
Abstract excerpt
Nasopharyngeal carcinoma (NPC) arises from the mucosal epithelium of the nasopharynx and is constantly associated with Epstein-Barr virus type 1 (EBV-1) infection. We carried out a genome-wide association study (GWAS) of 575,247 autosomal SNPs in 184 NPC patients and 236 healthy controls of Malaysian Chinese ethnicity. Potential association signals were replicated in a separate cohort of 260 NPC patients and 245...
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