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Article

The principal genetic determinants for nasopharyngeal carcinoma in China involve the HLA class I antigen recognition groove.

PLoS genetics - 1 Jan 2012

Tang Minzhong, Lautenberger James A, Gao Xiaojiang, Sezgin Efe, Hendrickson Sher L, Troyer Jennifer L, David Victor A, Guan Li, McIntosh Carl E, Guo Xiuchan, Zheng Yuming, Liao Jian, Deng Hong, Malasky Michael, Kessing Bailey, Winkler Cheryl A, Carrington Mary, Dé The Guy, Zeng Yi, O'Brien Stephen J

Abstract excerpt

Nasopharyngeal carcinoma (NPC) is an epithelial malignancy facilitated by Epstein-Barr Virus infection. Here we resolve the major genetic influences for NPC incidence using a genome-wide association study (GWAS), independent cohort replication, and high-resolution molecular HLA class I gene typing including 4,055 study participants from the Guangxi Zhuang Autonomous Region and Guangdong province of southern...

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Identifiers

PMID: 23209447
DOI: 10.1371/journal.pgen.1003103
PMCID: PMC3510037

Genes

GABBR1

Provenance

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