A regulatory mutant on TRIM26 conferring the risk of nasopharyngeal carcinoma by inducing low immune response.

doi:10.1002/cam4.1537

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

A regulatory mutant on TRIM26 conferring the risk of nasopharyngeal carcinoma by inducing low immune response.

Cancer medicine - 1 Aug 2018

Lyu Xiao-Ming, Zhu Xiao-Wei, Zhao Manli, Zuo Xian-Bo, Huang Zhong-Xi, Liu Xiao, Jiang Tao, Yang Xue-Xi, Li Xin, Long Xiao-Bing, Wang Jian-Guo, Li Jin-Bang, Han Ming-Yu, Wang Shuang, Liu Teng-Fei, Zhang Bo, Sun Tao, Cheng Zhi, Qiu Mo-Chang, Dong Lei, Zheng Lu, Zhang Long-Cheng, Wang Jia-Hong, Wei Gan-Guan, Yao Kaitai, Wang Qian, Zheng Hou-Feng, Li Xin

Abstract excerpt

The major histocompatibility complex (MHC) is most closely associated with nasopharyngeal carcinoma (NPC), but the complexity of its genome structure has proven challenging for the discovery of causal MHC loci or genes. We conducted a targeted MHC sequencing in 40 Cantonese NPC patients followed by a two-stage replication in 1065 NPC cases and 2137 controls of Southern Chinese descendent. Quantitative RT-PCR...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to High-Throughput Nucleotide Sequencing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunomodulation

Share to Killer Cells, Natural

Share to Leukocytes, Mononuclear

Share to Nasopharyngeal Carcinoma

Share to Neoplasm Staging

Share to Tripartite Motif Proteins

Share to Ubiquitin-Protein Ligases

Source

Open in PubMed Open full text

Identifiers

PMID: 29956500
DOI: 10.1002/cam4.1537
PMCID: PMC6089173

Genes

TRIM26

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A regulatory mutant on TRIM26 conferring the risk of nasopharyngeal carcinoma by inducing low immune response.PMID 29956500Read ↗

Nasopharyngeal carcinoma MHC region deep sequencing identifies HLA and novel non-HLA TRIM31 and TRIM39 loci.Semantic proximity Read ↗

An extended genome-wide association study identifies novel susceptibility loci for nasopharyngeal carcinoma.Semantic proximity Read ↗

Variations in the MHC region confer risk to esophageal squamous cell carcinoma on the subjects from high-incidence area in northern China.Semantic proximity Read ↗

A GWAS Meta-analysis and Replication Study Identifies a Novel Locus within CLPTM1L/TERT Associated with Nasopharyngeal Carcinoma in Individuals of Chinese Ancestry.Semantic proximity Read ↗

HLA-A SNPs and amino acid variants are associated with nasopharyngeal carcinoma in Malaysian Chinese.Semantic proximity Read ↗

Pan-cancer illumination of TRIM gene family reveals immunology regulation and potential therapeutic implications.Semantic proximity Read ↗

Homologous recombination deficiency (HRD) is associated with better prognosis and possibly causes a non-inflamed tumour microenvironment in nasopharyngeal carcinoma.Semantic proximity Read ↗

The principal genetic determinants for nasopharyngeal carcinoma in China involve the HLA class I antigen recognition groove.Semantic proximity Read ↗

Downregulation of CCL22 and mutated NOTCH1 in tongue and mouth floor squamous cell carcinoma results in decreased Th2 cell recruitment and expression, predicting poor clinical outcome.Semantic proximity Read ↗

Link between CIITA rs3087456 polymorphism and the risk of laryngeal squamous cell carcinoma in a Chinese population.Semantic proximity Read ↗

TRIM24 Overexpression Is Common in Locally Advanced Head and Neck Squamous Cell Carcinoma and Correlates with Aggressive Malignant PhenotypesSemantic proximity Read ↗

TRIM26 functions as a novel tumor suppressor of hepatocellular carcinoma and its downregulation contributes to worse prognosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.