D614G Spike Mutation Increases SARS CoV-2 Susceptibility to Neutralization.

doi:10.1016/j.chom.2020.11.012

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Article

D614G Spike Mutation Increases SARS CoV-2 Susceptibility to Neutralization.

Cell host & microbe - 13 Jan 2021

Weissman Drew, Alameh Mohamad-Gabriel, de Silva Thushan, Collini Paul, Hornsby Hailey, Brown Rebecca, LaBranche Celia C, Edwards Robert J, Sutherland Laura, Santra Sampa, Mansouri Katayoun, Gobeil Sophie, McDanal Charlene, Pardi Norbert, Hengartner Nick, Lin Paulo J C, Tam Ying, Shaw Pamela A, Lewis Mark G, Boesler Carsten, Şahin Uğur, Acharya Priyamvada, Haynes Barton F, Korber Bette, Montefiori David C

Abstract excerpt

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein acquired a D614G mutation early in the pandemic that confers greater infectivity and is now the globally dominant form. To determine whether D614G might also mediate neutralization escape that could compromise vaccine efficacy, sera from spike-immunized mice, nonhuman primates, and humans were evaluated for neutralization of...

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Identifiers

PMID: 33306985
DOI: 10.1016/j.chom.2020.11.012
PMCID: PMC7707640

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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