Article
Crucial Mutations of Spike Protein on SARS-CoV-2 Evolved to Variant Strains Escaping Neutralization of Convalescent Plasmas and RBD-Specific Monoclonal Antibodies.
Frontiers in immunology - 1 Jan 2021
Ding Chengchao, He Jun, Zhang Xiangyu, Jiang Chengcheng, Sun Yong, Zhang Yuqing, Chen Qingqing, He Hongliang, Li Wenting, Xie Jiajia, Liu Zhirong, Gao Yong
Abstract excerpt
Small number of SARS-CoV-2 epidemic lineages did not efficiently exhibit a neutralization profile, while single amino acid mutation in the spike protein has not been confirmed in altering viral antigenicity resulting in immune escape. To identify crucial mutations in spike protein that escape humoral immune response, we evaluated the cross-neutralization of convalescent plasmas and RBD-specific monoclonal...
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