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SARS-CoV-2 variants of concern: spike protein mutational analysis and epitope for broad neutralization

18 Aug 2022

Abstract excerpt

Abstract Mutations in the spike glycoproteins of SARS-CoV-2 variants of concern have independently been shown to enhance aspects of spike protein fitness. Here, we describe an antibody fragment (V H ab6) that neutralizes all major variants including the recently emerged BA.1 and BA.2 Omicron subvariants, with a unique mode of binding revealed by cryo-EM studies. Further, we provide a comparative analysis of the...

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PMID: 35982054
DOI: 10.1038/s41467-022-32262-8

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