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Article

The MOBSTER R package for tumour subclonal deconvolution from bulk DNA whole-genome sequencing data.

BMC bioinformatics - 17 Nov 2020

Caravagna Giulio, Sanguinetti Guido, Graham Trevor A, Sottoriva Andrea

Abstract excerpt

BACKGROUND: The large-scale availability of whole-genome sequencing profiles from bulk DNA sequencing of cancer tissues is fueling the application of evolutionary theory to cancer. From a bulk biopsy, subclonal deconvolution methods are used to determine the composition of cancer subpopulations in the biopsy sample, a fundamental step to determine clonal expansions and their evolutionary trajectories. RESULTS: In...

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PMID: 33203356
DOI: 10.1186/s12859-020-03863-1
PMCID: PMC7672894

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