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Article

The role of the SWI/SNF chromatin remodeling complex in pancreatic ductal adenocarcinoma

11 Dec 2020

Abstract excerpt

ATP-dependent chromatin remodeling complexes are a group of epigenetic regulators that can alter the assembly of nucleosomes and regulate the accessibility of transcription factors to DNA in order to modulate gene expression. One of these complexes, the SWI/SNF chromatin remodeling complex is mutated in more than 20% of human cancers. We have investigated the roles of the SWI/SNF complex in pancreatic ductal...

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PMID: 33301642
DOI: 10.1111/cas.14768

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