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Article

Survival differences and associated molecular signatures of DNMT3A-mutant acute myeloid leukemia patients.

Scientific reports - 29 Jul 2020

Lauber Chris, Correia Nádia, Trumpp Andreas, Rieger Michael A, Dolnik Anna, Bullinger Lars, Roeder Ingo, Seifert Michael

Abstract excerpt

Acute myeloid leukemia (AML) is a very heterogeneous and highly malignant blood cancer. Mutations of the DNA methyltransferase DNMT3A are among the most frequent recurrent genetic lesions in AML. The majority of DNMT3A-mutant AML patients shows fast relapse and poor survival, but also patients with long survival or long-term remission have been reported. Underlying molecular signatures and mechanisms that...

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Identifiers

PMID: 32728112
DOI: 10.1038/s41598-020-69691-8
PMCID: PMC7391693

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