Article
A prolonged exposure of human lung carcinoma epithelial cells to benzo[a]pyrene induces p21-dependent epithelial-to-mesenchymal transition (EMT)-like phenotype.
Chemosphere - 1 Jan 2021
Hýžďalová Martina, Procházková Jiřina, Strapáčová Simona, Svržková Lucie, Vacek Ondřej, Fedr Radek, Andrysík Zdeněk, Hrubá Eva, Líbalová Helena, Kléma Jiří, Topinka Jan, Mašek Josef, Souček Karel, Vondráček Jan, Machala Miroslav
Abstract excerpt
Deciphering the role of the aryl hydrocarbon receptor (AhR) in lung cancer cells may help us to better understand the role of toxic AhR ligands in lung carcinogenesis, including cancer progression. We employed human lung carcinoma A549 cells to investigate their fate after continuous two-week exposure to model AhR agonists, genotoxic benzo[a]pyrene (BaP; 1 μM) and non-genotoxic 2,3,7,8-tetrachlorodibenzo-p-dioxin...
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