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Article

Chronic inorganic arsenic exposure in vitro induces a cancer cell phenotype in human peripheral lung epithelial cells.

Toxicology and applied pharmacology - 1 Jul 2015

Person Rachel J, Ngalame Ntube N Olive, Makia Ngome L, Bell Matthew W, Waalkes Michael P, Tokar Erik J

Abstract excerpt

Inorganic arsenic is a human lung carcinogen. We studied the ability of chronic inorganic arsenic (2 μM; as sodium arsenite) exposure to induce a cancer phenotype in the immortalized, non-tumorigenic human lung peripheral epithelial cell line, HPL-1D. After 38 weeks of continuous arsenic exposure, secreted matrix metalloproteinase-2 (MMP2) activity increased to over 200% of control, levels linked to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25804888
DOI: 10.1016/j.taap.2015.03.014
PMCID: PMC4444387

Genes

AKT1
CDH1
HMOX1
KRAS
MMP2
PTEN
VIM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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