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Alterations of DNA methylation and mRNA levels of CYP1A1, GSTP1, and GSTM1 in human bronchial epithelial cells induced by benzo[a]pyrene.

Toxicology and industrial health - 1 Mar 2022

Liu Aixiang, Li Xin, Hao Zhongsuo, Cao Jingjing, Li Huan, Sun Min, Zhang Zhihong, Liang Ruifeng, Zhang Hongmei

Abstract excerpt

Benzo[a]pyrene (B[a]P) is a known human carcinogen and plays a major function in the initiation of lung cancer at its first proximity. However, the underlying molecular mechanisms are less well understood. In this study, we investigated the impact of B[a]P treatment on the DNA methylation and mRNA levels of CYP1A1, GSTP1, and GSTM1 in human bronchial epithelial cells (16HBEs), and provide scientific evidence for...

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PMID: 35193440
DOI: 10.1177/07482337211069233

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