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Article

Role of the Aryl Hydrocarbon Receptor in Carcinogenesis and Potential as a Drug Target

14 Jun 2013

Abstract excerpt

The aryl hydrocarbon receptor (AHR) is highly expressed in multiple organs and tissues, and there is increasing evidence that the AHR plays an important role in cellular homeostasis and disease. The AHR is expressed in multiple tumor types, in cancer cell lines, and in tumors from animal models, and the function of the AHR has been determined by RNA interference, overexpression, and inhibition studies. With few...

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PMID: 23771949
DOI: 10.1093/toxsci/kft128

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