Article
Induction of epithelial‐mesenchymal transition‐related genes by benzo[a]pyrene in lung cancer cells
8 Jun 2007
Abstract excerpt
BACKGROUND: It is believed that epithelial-mesenchymal transition (EMT) occurs during the development and progression of cancer; however, the correlation between tobacco smoking and EMT remains to be elucidated. METHODS: Cells from the bronchioloalveolar carcinoma cell line A549 were exposed to benzo(a)pyrene (B[a]P) for 24 weeks, and morphology, proliferative activity, and gene expression profiles were analyzed....
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