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Article

In utero exposure of mice to dibenzo[a,l]pyrene produces lymphoma in the offspring: role of the aryl hydrocarbon receptor.

Cancer research - 15 Jan 2006

Yu Zhen, Loehr Christiane V, Fischer Kay A, Louderback Mandy A, Krueger Sharon K, Dashwood Roderick H, Kerkvliet Nancy I, Pereira Clifford B, Jennings-Gee Jamie E, Dance Stephanie T, Miller Mark Steven, Bailey George S, Williams David E

Abstract excerpt

Lymphoma and leukemia are the most common cancers in children and young adults; in utero carcinogen exposure may contribute to the etiology of these cancers. A polycyclic aromatic hydrocarbon (PAH), dibenzo[a,l]pyrene (DBP), was given to pregnant mice (15 mg/kg body weight, gavage) on gestation day 17. Significant mortalities in offspring, beginning at 12 weeks of age, were observed due to an aggressive T-cell...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Leukemia, Lymphocytic, Chronic, B-Cell

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Share to Receptors, Aryl Hydrocarbon

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Source

Identifiers

PMID: 16424006
DOI: 10.1158/0008-5472.CAN-05-3390

Genes

AHR
DBP
PAH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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