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Article

The Value of BRAF VE1 Immunoexpression in Pediatric Langerhans Cell Histiocytosis.

Fetal and pediatric pathology - 1 Aug 2022

Phan Dang Anh Thu, Phung Gia Bao, Duong Thanh Tu, Hoang Anh Vu, Ngo Quoc Dat, Trinh Dinh The Nguyen, Tran Thanh Tung

Abstract excerpt

IntroductionVE1 is a monoclonal antibody detecting mutant BRAF V600E protein by immunohistochemistry (IHC) with a high concordance rate with molecular analysis in many cancers. Materials and methods: BRAF V600E mutation was assessed on 94 pediatric LCH patients using sequencing analysis and VE1 immunohistochemistry with stringent and lenient-scoring criteria. Results: BRAF V600E mutation exon 15 was detected by...

Topics

Antibodies, Monoclonal
Child
Histiocytosis, Langerhans-Cell
Humans
Immunohistochemistry
Mutation
Proto-Oncogene Proteins B-raf

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 33295826
DOI: 10.1080/15513815.2020.1857483

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-33295826-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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