Article
The Value of BRAF VE1 Immunoexpression in Pediatric Langerhans Cell Histiocytosis.
Fetal and pediatric pathology - 1 Aug 2022
Phan Dang Anh Thu, Phung Gia Bao, Duong Thanh Tu, Hoang Anh Vu, Ngo Quoc Dat, Trinh Dinh The Nguyen, Tran Thanh Tung
Abstract excerpt
IntroductionVE1 is a monoclonal antibody detecting mutant BRAF V600E protein by immunohistochemistry (IHC) with a high concordance rate with molecular analysis in many cancers. Materials and methods: BRAF V600E mutation was assessed on 94 pediatric LCH patients using sequencing analysis and VE1 immunohistochemistry with stringent and lenient-scoring criteria. Results: BRAF V600E mutation exon 15 was detected by...
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